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ABSTRACT. The present study aimed to evaluate the application of shear strength and its correlations with leaf blade morphological and chemical variables as a tool capable of detecting differences between species and accessions of the genus Paspalum in the early stages of a forage plant breeding programme. A total of 13 Paspalum accessions from two species (Paspalum atratum and Paspalum regnellii) were subjected to analyses of shear strength, which also analysed the neutral detergent fibre, acid detergent fibre, lignin, and digestibility. Morphological measurements were also performed to standardize the shear strength per unit of leaf tissue. The experimental design consisted of complete randomized blocks, with four replications and eight cuts performed over 2 years. Shear strength was evaluated for its potential usefulness for detecting differences between accessions of the same species and the correlations of accessions. It was possible to use the shear strength measured with the texturometer to detect differences between species and accessions of the Paspalum genus. The results showed significant correlations of shear strength and neutral detergent fibre (r = 0.49), and negative correlations were found between digestibility and shear strength (r = -0.55). These correlations were maintained when the strength variables were standardized according to the morphological variables. Thus, shear strength can be used in the initial stages of the selection of species of the genus Paspalum.

https://doi.org/10.4025/actasciagron.v45i1.56280

Gas exchange and leaf area requirement for yield in Cavendish and Gros Michel Bananas
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Donato, Sérgio Luiz Rodrigues

; Arantes, Alessandro de Magalhães

; Soares, Alex Rodrigues Silva

; Santos, Marcelo Rocha dos

; Rodrigues, Maria Geralda Vilela

Revista Brasileira de Fruticultura

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2023, Volume 45 elocation e-079

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The objective was to evaluate gas exchange and the leaf area requirement for yield in Cavendish and Gros Michel bananas. The cultivars Grande Naine, Calipso, Bucaneiro, FHIA-17 and FHIA-23, and two production cycles, were arranged in a completely randomized experimental design, in a factorial scheme, with five replicates. For the physiological characteristics, a 5x9x2 factorial arrangement was considered, with cultivars, evaluation periods and reading times. Cultivars Bucaneiro and Calipso require larger leaf area per unit produced and FHIA-23, smaller, which suggests a greater photosynthetic efficiency per leaf unit for FHIA-23, confirmed by the higher masses of bunches and hands and greater numbers of hands and fruits. Gas exchange varies with cultivars, evaluation periods and reading times. Cultivars FHIA-17 and Calipso, Gros Michel type, respectively showed higher photosynthesis and transpiration rates than Grande Naine, Cavendish type. Net photosynthesis, stomatal conductance, quantum efficiency of photosynthesis, instantaneous water use efficiency and carboxylation efficiency are higher at 8:00 h than at 14:00 h. The month of June allowed the cultivars to express the highest values of photosynthesis rates, incident radiation on leaves, carboxylation efficiency and stomatal conductance.

Resumo Objetivou-se avaliar trocas gasosas e requerimento em área foliar para rendimento de bananeiras Cavendish e Gros Michel. As cultivares, Grande Naine, Calipso, Bucaneiro, FHIA-17 e FHIA-23, e dois ciclos de produção foram dispostos em delineamento experimental inteiramente casualizado, em esquema fatorial, com cinco repetições. Para características fisiológicas, considerou-se arranjo fatorial 5 x 9 x 2, com cinco cultivares, nove períodos de avaliação e dois horários de leituras. As cultivares Bucaneiro e Calipso requerem maior área foliar por unidade produzida, e a FHIA-23, menor, o que sugere maior eficiência fotossintética por unidade de folha para esta, comprovada pelas maiores massas de cachos e de pencas, e maiores quantidades de pencas e frutos. As trocas gasosas variam com as cultivares, épocas de avaliação e horários de leitura. As cultivares FHIA-17 e Calipso, tipo Gros Michel, expressaram, respectivamente, maiores taxa de fotossíntese e de transpiração, que a Grande Naine, tipo Cavendish. A fotossíntese líquida, condutância estomática, e as eficiências quântica da fotossíntese, instantânea de uso da água e de carboxilação são maiores às 8 horas comparada às 14 horas. O mês de junho possibilitou às cultivares expressarem os maiores valores de taxas de fotossíntese, radiação incidente nas folhas, eficiência de carboxilação e condutância estomática.

https://doi.org/10.1590/0100-29452023079

Clinical, hematological, biochemical, and histopathological evaluations in domestic cats (Felis catus) infected by Leishmania infantum
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Batista, Joilson Ferreira

; Magalhães Neto, Francisco das Chagas Ribeiro

; Lopes, Kayo Sandro Pimentel do Prado

; Sousa, Carla Menezes Guimarães

; Alcântara, Diana Sousa

; Baêta, Sílvia de Araújo França

; Alves, Michel Muálem de Moraes

; Mendonça, Ivete Lopes de

Revista Brasileira de Parasitologia Veterinária

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2023, Volume 32 Nº 3 elocation e004723

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract A high frequency of feline leishmaniasis has been reported in several countries. However, much information about disease progression in cats still needs to be clarified. This study aimed to verify the occurrence of clinicopathological changes in cats infected with Leishmania infantum. A total of 60 cats were divided into three groups of 20 animals each: control, suspects, and infected. All 60 cats underwent blood count and biochemical analyses. Serum samples from 20 animals with leishmaniasis were also used to diagnose feline immunodeficiency virus and feline leukemia virus. A total of five of the infected animals underwent necropsy for a histopathological study. The main clinical findings in cats with leishmaniasis were lymphadenomegaly (65%), alopecia (55%), ulcerative skin lesions and weight loss (40%), skin nodules (25%), a significant reduction in red blood cells (p=0.0005) and hematocrit (p=0.0007), hyperplasia in spleen 4/5(80%), presence of Leishmania in the spleen 2/5(40%), hepatitis 3/5(60%), liver degeneration 4/5(80%) and inflammatory nephropathy 3/5(60%). It was concluded that cats with leishmaniasis presented significant clinical, hematological, and histopathological alterations compatible with L. infantum infection. The observation of lymphadenomegaly, weight loss, skin lesions and low concentration of red blood cells, contributes significantly to the diagnosis and analysis of progression of feline leishmaniasis.

Resumo Uma alta frequência de leishmaniose felina tem sido relatada em vários países. No entanto, muitas informações sobre a progressão da doença em gatos ainda precisam ser esclarecidas. Este estudo teve como objetivo verificar a ocorrência de alterações clinicopatológicas em gatos infectados por Leishmania infantum. Um total de 60 gatos foi dividido em três grupos de 20 animais cada: controle, suspeitos e infectados. Todos os 60 gatos foram submetidos à hemograma e testes bioquímicos. Amostras de soro de 20 animais com leishmaniose também foram utilizadas para diagnosticar o vírus da imunodeficiência felina e o vírus da leucemia felina. Um total de cinco dos animais infectados foram necropsiados para estudo histopatológico. Os principais achados clínicos nos gatos com leishmaniose foram linfadenomegalia (65%), alopecia (55%), lesões ulcerativas na pele e emagrecimento (40%), nódulos cutâneos (25%), redução significativa de hemácias (p=0,0005) e hematócrito (p=0,0007), hiperplasia no baço 4/5(80%), presença de Leishmania no baço 2/5(40%), hepatite 3/5(60%), degeneração hepática 4/5(80%) e nefropatia inflamatória 3/5(60%). Concluiu-se que gatos com leishmaniose apresentaram alterações clínicas, hematológicas e histopatológicas significativas compatíveis com infecção por L. infantum. A observação de linfadenomegalia, emagrecimento, lesões cutâneas e baixa concentração de hemácias, contribui significativamente para o diagnóstico e análise da progressão da leishmaniose felina.

https://doi.org/10.1590/s1984-29612023037

Characterization of the organic matter in pockmark areas of the Southwestern Atlantic upper slope
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Lourenço, Rafael André

; Kunrath, Nathalia Araujo

; Nagaoka, Doris

; Magalhães, Caio Augusto

; Pereira, Antonio Derley de Sousa

; Sotão Neto, Basílio Magno Tavares

; Timoszczuk, Cristian Taboada

; Santos, Felipe Rodrigues dos

; Pedrão, Guilherme Augusto

; Araujo, Lígia Dias de

; Nascimento, Lorena Sampaio

; Carvalho, Nayara Ferreira

; Silva, Josilene da

; Taniguchi, Satie

; Mahiques, Michel Michaelovitch de

; Bícego, Márcia Caruso

; Sumida, Paulo Yukio Gomes

Ocean and Coastal Research

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2022, Volume 70 Supl. 2 elocation e22028

Resumo: En | Texto: En | PDF: En

Abstract Pockmarks are circular or elliptical structures formed at the seabed by the expulsion of gas from the subsurface. They are widely distributed along the continental margin off southeastern Brazil and can be over a kilometer wide and 100 meters deep. However, studies concerning the organic characteristics of these pockmark areas are scarce. This study sought to evaluate the organic composition of the sedimentary matter in pockmark areas located in the continental slope region of the southern Brazilian coast. Hydrocarbons, sterols, long-chain alcohols, stable isotopes of C and N, total organic carbon, and total nitrogen were assessed to provide an organic molecular characterization of the pockmarks located in the Southwestern Atlantic Ocean. These compounds did not reflect the organic characteristics of the scape of fluids that generate pockmark structures.

https://doi.org/10.1590/2675-2824070.22022ral

Fast surveillance response reveals the introduction of a new yellow fever virus sub-lineage in 2021, in Minas Gerais, Brazil
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Andrade, Miguel Souza

; Campos, Fabrício Souza

; Oliveira, Cirilo Henrique de

; Oliveira, Ramon Silva

; Campos, Aline Alves Scarpellini

; Almeida, Marco Antônio Barreto de

; Fonseca, Vagner de Souza

; Simonini-Teixeira, Danilo

; Sevá, Anaiá da Paixão

; Temponi, Andrea Oliveira Dias

; Magalhães, Fernando Maria

; Chaves, Danielle Costa Capistrano

; Pereira, Maira Alves

; Lamounier, Ludmila Oliveira

; Menezes, Givaldo Gomes de

; Aquino-Teixeira, Sandy Micaele

; Gonçalves-dos-Santos, Maria Eduarda

; Bernal-Valle, Sofía

; Müller, Nicolas Felipe Drumm

; Cardoso, Jader da Cruz

; Santos, Edmilson dos

; Mares-Guia, Maria Angélica

; Albuquerque, George Rêgo

; Romano, Alessandro Pecego Martins

; Franco, Ana Cláudia

; Ribeiro, Bergmann Morais

; Roehe, Paulo Michel

; Abreu, Filipe Vieira Santos de

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e220127

Resumo: En | Texto: En | PDF: En

BACKGROUND In Brazil, the yellow fever virus (YFV) is maintained in a sylvatic cycle involving wild mosquitoes and non-human primates (NHPs). The virus is endemic to the Amazon region; however, waves of epidemic expansion reaching other Brazilian states sporadically occur, eventually causing spillovers to humans. OBJECTIVES To report a surveillance effort that led to the first confirmation of YFV in NHPs in the state of Minas Gerais (MG), Southeast region, in 2021. METHODS A surveillance network was created, encompassing the technology of smartphone applications and coordinated actions of several research institutions and health services to monitor and investigate NHP epizootics. FINDINGS When alerts were spread through the network, samples from NHPs were collected and YFV infection confirmed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and genome sequencing at an interval of only 10 days. Near-complete genomes were generated using the Nanopore MinION sequencer. Phylogenetic analysis indicated that viral genomes were related to the South American genotype I, clustering with a genome detected in the Amazon region (state of Pará) in 2017, named YFVPA/MG sub-lineage. Fast YFV confirmation potentialised vaccination campaigns. MAIN CONCLUSIONS A new YFV introduction was detected in MG 6 years after the beginning of the major outbreak reported in the state (2015-2018). The YFV strain was not related to the sub-lineages previously reported in MG. No human cases have been reported, suggesting the importance of coordinated surveillance of NHPs using available technologies and supporting laboratories to ensure a quick response and implementation of contingency measures to avoid YFV spillover to humans.

https://doi.org/10.1590/0074-02760220127

Methane-related community of a carbonate-enriched pockmark, Brazilian Southeastern continental slope
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Nakamura, Fernanda Mancini

; Lourenço, Rafael Andre

; Magalhães, Caio Augusto

; Bendia, Amanda Gonçalves

; Butarelli, Ana Carolina de Araújo

; Passos, Julia Gasparini

; Soares, Luiza Ferreira

; Ramos, Raissa Basti

; Trevizani, Tailisi Hoppe

; Signori, Camila Negrão

; Mahiques, Michel Michaelovitch de

; Sumida, Paulo Yukio Gomes

; Pellizari, Vivian Helena

Ocean and Coastal Research

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2022, Volume 70 Supl. 2 elocation e22046

Resumo: En | Texto: En | PDF: En

Abstract Pockmarks are geological features that often sustain hydrocarbon-related communities of microorganisms when active, seeping oil or methane. Microbial communities of inactive pockmarks have not been well studied until the present. Plenty of pockmarks in the Southwestern Atlantic Ocean have been discovered. However, no information is available about the organic characteristics in association with the microbial diversity related to methane and non-methane hydrocarbon consumption. This study examined the identity and potential ecology of the methane-related microbial community in an inactive SW Atlantic Carbonate-enriched Pockmark (SWACP). Undisturbed sediment cores were enriched with CH4 99.5% at 5°C, with samples harvested at 16h, 120h, 240h, 720h, and 960h, followed by metataxonomics functional prediction, and the correlation of microbial groups with incubation and enrichment types. The SWACP is depleted in organic compounds, and chemosynthetic production is dominant. Incubated mini-cores of sediment were affected by incubation time and enrichment type, which influenced the microbial composition. Although several taxa were shared among all sediment samples, specific groups per enrichment type and incubation time were observed. These communities comprised taxa previously reported in marine bottom waters, carbonate crusts, active cold-seeps, and inactive pockmarks. The methane-enriched taxa were predominantly related to aerobic methanotrophy, methylotrophy, aerobic and anaerobic non-methane hydrocarbon degradation, and fermentation. This study brings the first survey of the key microbial groups in methane fluxes of a Brazilian deep-sea pockmark, providing data for understanding the ecology surrounding the SW Atlantic gas field areas.

https://doi.org/10.1590/2675-2824070.22071fmn

Effect of combined physical exercise program on improving the functional capacity and the cardiac autonomic modulation of Chagas cardiomyopathy
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Bavel, Diogo Van

; Souza, Wallace Machado Magalhães de

; Nery, Yan de Britto

; Amorin, Juliana Nascimento

; Pedrosa, Roberto Coury

; Reis, Michel Silva

Motriz: Revista de Educação Física

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2021, Volume 27 elocation e1021017720

Resumo: En | Texto: En | PDF: En

Abstract Aims: Patients with Chagas cardiomyopathy (ChC) could have a significant reduction in functional capacity (FC). This study aimed to report the effect of a 24-week combined physical exercise program on the FC of a patient with ChC. Methods: A woman, 44 years old, with positive serology for ChC in stage B2 has submitted the following assessments: i) Physical assessment: ii) Cardiopulmonary exercise test; iii) Test of 1-maximum Repetition, iv) Evaluation of cardiac autonomic modulation by heart rate variability (HRV). Results: The results obtained revealed a reduction in the anthropometric parameters and the SBP after training. Additionally, we observed an improvement in FC (aerobic and strength condiction) and cardiac autonomic modulation after 24 weeks of combined training. Conclusion: Our findings show that of a 24-week combined physical exercise program improved either FC or HRVof the patient with ChC.

https://doi.org/10.1590/s1980-657420210017720 290 downloads

Management of acute stroke and urgent neurointerventional procedures during COVID-19 pandemic: recommendations on the Scientific Department on Cerebrovascular Diseases of the Brazilian Academy of Neurology, Brazilian Society of Cerebrovascular Diseases and Brazilian Society of Neuroradiology
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MONT’ALVERNE, Francisco José Arruda

; LIMA, Fabrício Oliveira

; NOGUEIRA, Raul Gomes

; FREITAS, Carlos Clayton Macedo de

; NETO, Octávio Marques Pontes

; SILVA, Gisele Sampaio

; OLIVEIRA, Maura Salaroli de

; FRUDIT, Michel

; CALDAS, Jose Guilherme Mendes Pereira

; ABUD, Daniel Giansante

; CONFORTO, Adriana Bastos

; CARVALHO, Fernanda Martins Maia

; DIAS, Francisco Antunes

; BAZAN, Rodrigo

; AVELAR, Wagner Mauad

; MORO, Carla Heloísa Cabral

; MAGALHÃES, Pedro Silva Correa de

; MIRANDA, Maramelia

; BARBOSA, Leandro de Assis

; FIOROT JUNIOR, José Antonio

; CARDOSO, Fabrício Buchdid

; REBELLO, Leticia Costa

; PARENTE, Bruno de Sousa Mendes

; FARIA, Mário de Barros

; FREITAS, Gabriel Rodriguez de

; ZÉTOLA, Viviane de Hiroki Flumignan

; OLIVEIRA-FILHO, Jamary

; BEZERRA, Daniel da Cruz

; RODRIGUES, Jorge Luis Nobre

; KUSTER, Gustavo

; MARTINS, Sheila

; CARVALHO, João José Freitas de

Arquivos de Neuro-Psiquiatria

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Jul 2020, Volume 78 Nº 7 Páginas 440 - 449

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: A pandemia causada pelo novo coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2, COVID-19) apresenta novos e importantes desafios à gestão de saúde no Brasil. Além da difícil missão de prestar atendimento aos milhares de pacientes infectados pelo COVID-19, os sistemas de saúde têm que manter a assistência às emergências médicas comuns em períodos sem pandemia, tais como o acidente vascular cerebral (AVC), que continuam ocorrendo e requerem tratamento com presteza e eficiência. A alocação de recursos materiais e humanos para o enfrentamento à pandemia não pode comprometer o atendimento ao AVC agudo, uma emergência cujo tratamento é tempo-dependente e se não realizado implica em importante impacto na mortalidade e incapacitação a longo prazo. Objetivo: Este trabalho resume as recomendações do Departamento Científico de Doenças Cerebrovasculares da Academia Brasileira de Neurologia, da Sociedade Brasileira de Doenças Cerebrovasculares e da Sociedade Brasileira de Neurorradiologia para o tratamento do AVC agudo e para a realização de procedimentos de neurointervenção urgentes durante a pandemia de COVID-19, incluindo o uso adequado de ferramentas de triagem e equipamentos de proteção pessoal (para pacientes e profissionais de saúde), além da alocação apropriada de pacientes.

ABSTRACT Introduction: Although the 2019 severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2, COVID-19) pandemic poses new challenges to the healthcare system to provide support for thousands of patients, there is special concern about common medical emergencies, such as stroke, that will continue to occur and will require adequate treatment. The allocation of both material and human resources to fight the pandemic cannot overshadow the care for acute stroke, a time-sensitive emergency that with an inefficient treatment will further increase mortality and long-term disability. Objective: This paper summarizes the recommendations from the Scientific Department on Cerebrovascular Diseases of the Brazilian Academy of Neurology, the Brazilian Society of Cerebrovascular Diseases and the Brazilian Society of Neuroradiology for management of acute stroke and urgent neuro-interventional procedures during the COVID-19 pandemic, including proper use of screening tools, personal protective equipment (for patients and health professionals), and patient allocation.

https://doi.org/10.1590/0004-282x20200053 2310 downloads

Diálogo do front: pandemia e (in)capacidade governamental
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Anjos, Denise

; Magalhães, Michel

Physis: Revista de Saúde Coletiva

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2020, Volume 30 Nº 3 elocation e300303

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.1590/s0103-73312020300303

10.

Diálogo do front: pandemia e (in)capacidade governamental
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Anjos, Denise

; Magalhães, Michel

Physis: Revista de Saúde Coletiva

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2020, Volume 30 Nº 3 elocation e300303

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.1590/s0103-73312020300303 693 downloads

11.

Management of ophthalmic surgical instruments and processes optimization: mixed method study
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Schneider, Daniela Silva dos Santos

; Magalhães, Ana Maria Müller de

; Glanzner, Cecilia Helena

; Thomé, Elisabeth Gomes da Rocha

; Oliveira, João Lucas Campos de

; Anzanello, Michel José

Revista Gaúcha de Enfermagem

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2020, Volume 41 elocation e20190111

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: Analisar o uso de instrumentais oftalmológicos durante os procedimentos cirúrgicos e propor um método de gerenciamento de materiais. Método: Estudo de método misto, exploratório sequencial, realizado entre janeiro e junho de 2015, em hospital universitário no sul do Brasil. Primeiramente, fez-se uma abordagem qualitativa a partir de brainstorming e observação de campo. Os temas foram agrupados em categorias temáticas. Por conexão, a etapa quantitativa aconteceu por arranjos de matrizes e programação linear, culminando à proposta de gerenciamento de instrumentais. Resultados: As categorias - reorganização do instrumental conforme tempo do procedimento cirúrgico e necessidade de peças para cada procedimento - orientaram a definição das restrições existentes e aplicação dos modelos matemáticos. Verificou-se uma redução média de 13,10% no número de peças por bandejas e aumento de 17,88% da produção cirúrgica. Considerações finais: Esta proposta permitiu a racionalização e otimização de instrumentais oftalmológicos, favorecendo a sustentabilidade da organização.

ABSTRACT Aim: Analysis of the use of ophthalmic instruments during surgical procedures in order to propose a material management method. Method: Mixed method study, sequential exploratory design, performed from January to June 2015, at a university hospital in southern Brazil. First, a qualitative approach was held from brainstorming and field observation. Themes were grouped into thematic categories. By connection, the quantitative stage happened through matrix arrangement and linear programming, culminating in the instrument management proposal. Results: Given categories - instruments reorganization according to the time of the surgical procedure and the need surgical instruments for in each procedure - guided the definition of existing restrictions and application of mathematical models. There was an average reduction of 13.10% in the number of surgical instruments per tray and an increase of 17.88% in surgical production. Final considerations: This proposal allowed the rationalization and optimization of ophthalmic instruments, favoring sustainability of the organization.

RESUMEN Objetivo: Analizar el uso de instrumentos oftalmológicos durante los procedimientos quirúrgicos y proponer un método de gestión de materiales. Método: Estudio de método mixto, exploratorio secuencial, realizado entre enero y junio de 2015, en un hospital universitario en el sur de Brasil. Primero, se realizó un enfoque cualitativo a partir de la reflexión y la observación de campo. Los temas se agruparon en categorías temáticas. Por conexión, la etapa cuantitativa ocurrió por arreglos de matrices y programación linear, culminando con la propuesta de gestión de instrumentales. Resultados: Las categorías - reorganización del instrumental conforme tiempo del procedimiento quirúrgico y necesidad de piezas para cada procedimiento - orientaron la definición de las restricciones existentes y aplicación de los modelos matemáticos. Verificó una reducción media del 13,10% en el número de piezas por bandejas y aumento del 17,88% de la producción quirúrgica. Consideraciones finales: Esta propuesta permitió la racionalización y optimización de instrumentos oftalmológicos, favoreciendo la sostenibilidad de la organización.

https://doi.org/10.1590/1983-1447.2020.20190111 1361 downloads

12.

Management of ophthalmic surgical instruments and processes optimization: mixed method study
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Schneider, Daniela Silva dos Santos

; Magalhães, Ana Maria Müller de

; Glanzner, Cecilia Helena

; Thomé, Elisabeth Gomes da Rocha

; Oliveira, João Lucas Campos de

; Anzanello, Michel José

Revista Gaúcha de Enfermagem

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2020, Volume 41 elocation e20190111

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/1983-1447.2020.20190111 30 downloads

13.

Seroprevalence for equine infectious anaemia in Equidae seized in the municipality of Petrópolis, State of Rio de Janeiro, Brazil, 2015/2018
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Cruz, Astrid Paola Mattheis

; Aquino, Maria Helena Consedey de

; Helayael, Michel José Sales Abdalla

; Silva, Márcio Roberto

; Ribeiro, João Batista

; Hott, Marcos Cicarini

; Magalhães Júnior, Walter Coelho Pereira de

; Mendonça, Juliana França Monteiro de

; Souza, Guilherme Nunes de

Ciência Rural

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2020, Volume 50 Nº 4 elocation e20190073

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: A anemia infecciosa equina (AIE) é uma doença globalmente distribuída causada por um lentivírus. AIE é uma doença de notificação obrigatória que deve ser relatada ao Serviço Veterinário Oficial (SVO), e os surtos são controlados pelo sacrifício dos animais positivos para AIE. O presente estudo analisou a prevalência de AIE em 165 equídeos apreendidos em vias públicas no município de Petrópolis, estado do Rio de Janeiro, Brasil, no período de 2015 a 2018. Após a apreensão e identificação dos equídeos seu sangue foi coletado para diagnosticar a AIE. Observou-se uma prevalência real de 11,8% entre os equídeos apreendidos, sendo que o principal fator de risco identificado foi a região de apreensão. O Mapa de Kernel mostrou que as áreas com maior densidade de equídeos positivos estavam no centro e leste da área de estudo. Nesta região, houve maior chance (OR = 3,6) de apreender um animal positivo para AIE em relação ao da outra região, composto pelos 34 locais restantes. A implementação e manutenção de apreensão de equídeos e posterior teste de diagnóstico para AIE no município de Petrópolis, RJ, mostrou-se de grande importância para o controle e prevenção da doença. A indicação do local da apreensão nos cartões de identificação dos animais possibilitou um delineamento dos locais no município de Petrópolis, RJ, que apresentavam maior risco de animais positivos para AIE.

ABSTRACT: Equine infectious anaemia (EIA) is a globally distributed disease caused by a lentivirus. EIA is a notifiable disease that should be reported to the Official Veterinary Service (SVO). Outbreaks are controlled by sacrificing the EIA-positive animals. The study analysed the prevalence of EIA in 165 Equidae seized on public roads in the municipality of Petrópolis, Rio de Janeiro, Brazil, from 2015 to 2018. After the seizure and identification of the Equidae, blood was collected to diagnose EIA. A prevalence of 11.8% was observed among the Equidae seized, and the main risk factor was the region of seizure. A kernel-smoothed map showed areas with the highest density of EIA-positive Equidae in the centre and to the east of the study area. In this region, the chance of seizing an equine positive for EIA was greater (OR=3.6) relative to the remaining region. The implementation and maintenance of Equidae seizures and subsequent diagnostic testing for EIA in the municipality of Petrópolis were shown to have great importance for the control and prevention of the disease. Indicating the place of seizure on the identification cards of the animals enabled delineation of the locations in the municipality of Petrópolis, that had a higher risk of EIA-positive animals.

https://doi.org/10.1590/0103-8478cr20190073 855 downloads

14.

Effectiveness of monthly and fortnightly anti-VEGF treatments for age-related macular degeneration
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Nunes, Renata Portella

; Hirai, Flávio Eduardo

; Barroso, Letícia Fernandes

; Badaró, Emmerson

; Novais, Eduardo

; Rodrigues, Eduardo Buchele

; Maia, Mauricio

; Magalhães Jr., Octaviano

; Farah, Michel Eid

Arquivos Brasileiros de Oftalmologia

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Jun 2019, Volume 82 Nº 3 Páginas 225 - 232

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Estudar a eficácia e segurança dos tratamentos com ranibizumabe e bevacizumabe para a degeneração macular relacionada à idade exsudativa. Métodos: Ensaio clínico paralelo randomizado foi conduzido para comparar a eficácia e segurança de três regimes (bevacizumabe a cada mês, bevacizumabe a cada 2 semanas e ranibizumabe todos os meses), seguidos por retratamentos conforme necessidade, durante 1 ano, em indivíduos previamente não tratados com degeneração macular relacionada à idade. O desfecho primário foi alteração na acuidade visual e na espessura macular central após um ano de seguimento. Os indivíduos foram designados aleatoriamente para um dos 3 grupos em uma proporção de 1:1:1, e os investigadores e examinadores foram mascarados para os resultados da randomização. Resultados: Foram incluídos 15 pacientes em cada grupo. Após um ano de seguimento, encontramos melhorias estatisticamente significativas na acuidade visual e na redução da espessura macular central em todos os grupos. No entanto, não encontramos diferenças estatisticamente significativas entre os 3 grupos. Conclusões: O seguimento quinzenal foi eficaz e não encontramos diferenças significativas na eficácia ou segurança entre os tratamentos com bevacizumabe e ranibizumabe.

ABSTRACT Purpose: To study the efficacy and safety of treatments with ranibizumab and bevacizumab for exudative age-related macular degeneration. Methods: A parallel randomized clinical trial was conducted to compare the efficacy and safety of three regimens (bevacizumab every month, bevacizumab every 2 weeks, and ranibizumab every month), followed by as-needed retreatments, for 1 year, in previously untreated individuals with age-related macular degeneration. The primary outcome was change in visual acuity and in central macular thickness after 1 year of follow-up. Subjects were assigned randomly to one of the three groups in a 1:1:1 ratio, and investigators and examiners were blinded to the randomization results. Results: We included 15 patients in each group. After 1 year of follow-up, we found statistically significant improvements in visual acuity and central macular thickness reduction in all groups. However, we found no statistically significant differences between the three groups. Conclusions: The bi-weekly follow-up was effective and we found no significant differences in efficacy or safety between the treatments with ranibizumab and bevacizumab.

https://doi.org/10.5935/0004-2749.20190043 1038 downloads

15.

Brazilian recommendations on the safety and effectiveness of the yellow fever vaccination in patients with chronic immune-mediated inflammatory diseases
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Pileggi, Gecilmara Salviato

; Mota, Licia Maria Henrique Da

; Kakehasi, Adriana Maria

; Souza, Alexandre Wagner De

; Rocha, Aline

; Melo, Ana Karla Guedes de

; Fonte, Caroline Araujo M. da

; Bortoletto, Cecilia

; Brenol, Claiton Viegas

; Marques, Claudia Diniz Lopes

; Zaltman, Cyrla

; Borba, Eduardo Ferreira

; Reis, Enio Ribeiro

; Freire, Eutilia Andrade Medeiros

; Klumb, Evandro Mendes

; Christopoulos, Georges Basile

; Laurindo, Ieda Maria M.

; Ballalai, Isabella

; Costa, Izaias Pereira Da

; Michelin, Lessandra

; Valadares, Lilian David de Azevêdo

; Chebli, Liliana Andrade

; Lacerda, Marcus

; Toscano, Maria Amazile Ferreira

; Yazbek, Michel Alexandre

; Vieira, Rejane Maria R. De Abreu

; Magalhães, Renata

; Kfouri, Renato

; Richtmann, Rosana

; Merenlender, Selma Da Costa Silva

; Valim, Valeria

; Assis, Marcos Renato De

; Kowalski, Sergio Candido

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2019, Volume 59 elocation 17

Resumo: En | Texto: En | PDF: En

Abstract Background: In Brazil, we are facing an alarming epidemic scenario of Yellow fever (YF), which is reaching the most populous areas of the country in unvaccinated people. Vaccination is the only effective tool to prevent YF. In special situations, such as patients with chronic immune-mediated inflammatory diseases (CIMID), undergoing immunosuppressive therapy, as a higher risk of severe adverse events may occur, assessment of the risk-benefit ratio of the yellow fever vaccine (YFV) should be performed on an individual level. Main body of the abstract: Faced with the scarcity of specific orientation on YFV for this special group of patients, the Brazilian Rheumatology Society (BRS) endorsed a project aiming the development of individualized YFV recommendations for patients with CIMID, guided by questions addressed by both medical professionals and patients, followed an internationally validated methodology (GIN-McMaster Guideline Development). Firstly, a systematic review was carried out and an expert panel formed to take part of the decision process, comprising BRS clinical practitioners, as well as individuals from the Brazilian Dermatology Society (BDS), Brazilian Inflammatory Bowel Diseases Study Group (GEDIIB), and specialists on infectious diseases and vaccination (from Tropical Medicine, Infectious Diseases and Immunizations National Societies); in addition, two representatives of patient groups were included as members of the panel. When the quality of the evidence was low or there was a lack of evidence to determine the recommendations, the decisions were based on the expert opinion panel and a Delphi approach was performed. A recommendation was accepted upon achieving ≥80% agreement among the panel, including the patient representatives. As a result, eight recommendations were developed regarding the safety of YFV in patients with CIMID, considering the immunosuppression degree conferred by the treatment used. It was not possible to establish recommendations on the effectiveness of YFV in these patients as there is no consistent evidence to support these recommendations. Conclusion: This paper approaches a real need, assessed by clinicians and patient care groups, to address specific questions on the management of YFV in patients with CIMID living or traveling to YF endemic areas, involving specialists from many areas together with patients, and might have global applicability, contributing to and supporting vaccination practices. We recommended a shared decision-making approach on taking or not the YFV.

https://doi.org/10.1186/s42358-019-0056-x 1111 downloads

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